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BioPython Integration

Support for BioPython Structure objects.

Installation​

pip install zsasa[biopython]
# or
uv add zsasa[biopython]

Import​

from zsasa.integrations.biopython import (
    calculate_sasa_from_structure,
    calculate_sasa_from_model,
    extract_atoms_from_model,
)

Supported Formats​

  • PDB (.pdb)
  • mmCIF (.cif)

Example​

from zsasa.integrations.biopython import calculate_sasa_from_structure

# From file
result = calculate_sasa_from_structure("protein.pdb")

# From BioPython Structure
from Bio.PDB import PDBParser
parser = PDBParser(QUIET=True)
structure = parser.get_structure("protein", "protein.pdb")
result = calculate_sasa_from_structure(structure)

# Access results
print(f"Total: {result.total_area:.1f} Ų")

When to Use​

  • Existing BioPython workflows
  • Need BioPython's other features (sequence alignment, etc.)